The role of tissue hypoxia in the evolution of kidney disease

我们将确定肾脏中的低氧水平如何导致肾脏疾病。我们现在可以一周7天、每天24小时测量大鼠肾脏组织中的氧气水平，这是一种完全无创的方法。我们将研究两种常见的肾脏疾病。一种是急性肾损伤，可能是在X光诊断程序中使用造影剂造成的。另一种是慢性肾脏疾病，在糖尿病或高血压患者中很常见。

We will determine how low oxygen levels in the kidney lead to kidney disease. We can now measure the levels of oxygen in kidney tissue in rats 24 hours a day, 7 days a week, in a completely non-invasive way. We will study two common kinds of kidney disease. One, acute kidney injury, can result from administration of contrast agents used in x-ray diagnostic procedures. The other, chronic kidney disease, is common in patients with diabetes or high blood pressure.