New data-driven mathematical models of collective cell motion

癌症和慢性伤口是一个国家，实际上是一个国际健康问题，随着我们人口的老龄化而恶化。需要预测和解释工具来提高我们对与癌症和慢性伤口有关的集体细胞迁移的理解。该项目将产生新的经过验证的数学工具，用于在一般框架中预测集体细胞迁移，该框架可以处理特定应用的细节，例如细胞形状和细胞大小的作用。虽然已知细胞的形状和大小会影响细胞的集体迁移，但标准的数学模型忽略了这些细节。该项目将产生新的预测数学建模工具，并通过新的实验数据进行验证。

Cancer and chronic wounds are a national, and indeed, international health problem set to worsen as our population ages. Predictive and interpretive tools are required to improve our understanding of collective cell migration in relation to cancer and chronic wounds. This project will produce new validated mathematical tools for predicting collective cell migration in a general framework that can deal with application-specific details, such as the role of cell shape and cell size. Although cell shape and size are known to affect collective cell migration, standard mathematical models ignore these details. This project will produce new predictive mathematical modelling tools that are validated by new experimental data.