Mathematical models of 4D multicellular spheroids

4D 多细胞球体的数学模型

• 批准号: DP200100177
• 负责人: Prof Matthew Simpson
• 金额: $ 34.75万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-03 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100177
• 关键词: Mathematical; models; 4D; multicellular; spheroids

Mathematical models have a long, successful history of providing biological insight, and new mathematical models must be developed to keep pace with emerging technologies. Modern experimental procedures involve studying 3D multicellular spheroids with fluorescent labels to show both the location of cells and the cell cycle progression. This 4D data (3D spatial information + cell cycle time) provides vast information. No mathematical models have been specifically developed to interpret/predict 4D spheroids. This project will deliver the first high-fidelity mathematical models to interpret/predict 4D spheroid experiments in real time, providing quantitative insight into innate mechanisms and responses to various intervention treatments.

数学模型在提供生物学见解方面有着悠久而成功的历史，必须开发新的数学模型以跟上新兴技术的步伐。 现代实验程序涉及研究具有荧光标记的3D多细胞球体，以显示细胞的位置和细胞周期进程。 这种4D数据（3D空间信息+细胞周期时间）提供了大量信息。 没有专门开发数学模型来解释/预测4D球体。 该项目将提供第一个高保真的数学模型来解释/预测4D球体实验在真实的时间，提供定量的洞察先天机制和各种干预治疗的反应。