A new hierarchy of mathematical models to quantify the role of ghrelin during cell invasion

一种新的数学模型层次来量化生长素释放肽在细胞侵袭过程中的作用

• 批准号: DP140100249
• 负责人: Prof Matthew Simpson
• 金额: $ 20.42万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-10-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140100249
• 关键词: new; hierarchy; mathematical; models; quantify

Ghrelin is a recently-discovered growth factor that regulates appetite and promotes tumour growth by enhancing cell invasion. The mechanisms by which ghrelin enhances cell invasion are, at present, unknown. This innovative project will develop a new hierarchy of multiscale mathematical models that will be used to quantify how ghrelin modulates cell behaviour (motility, proliferation and death) and provide insight into the precise details of how ghrelin promotes cell invasion. This project will demonstrate the potential for ghrelin-based strategies to control cell invasion. By linking appetite regulation and tumour growth, the outcomes from this project will inform Australian health policy in this important area.

Ghrelin是最近发现的一种生长因子，可以调节食欲并通过增强细胞侵袭来促进肿瘤生长。生长激素释放肽增强细胞侵袭的机制目前尚不清楚。这个创新项目将开发一个新的多尺度数学模型层次，用于量化ghrelin如何调节细胞行为（运动，增殖和死亡），并提供ghrelin如何促进细胞入侵的精确细节。该项目将展示基于ghrelin的策略来控制细胞入侵的潜力。通过将食欲调节和肿瘤生长联系起来，该项目的成果将为澳大利亚在这一重要领域的卫生政策提供信息。