S100 proteins: novel oxidant scavengers in allergic inflammation

过敏性炎症包括皮炎和哮喘。哮喘影响着十分之一的成年人和六分之一的澳大利亚人，每年花费约7.2亿美元。我们将描述对关键致病过程有抑制作用的新的氧化防御介质。S100蛋白的新氧化变化可能导致新的诊断试剂和新的治疗策略。研究结果将为哮喘生物学开辟新的领域，并将应用于其他慢性炎症性疾病。

Allergic inflammation includes conditions such as dermatitis and asthma. Asthma, affects one in 10 adults and one in 6 Australians, costing ~$720 million/annum. We will characterize new mediators of oxidant defence which have suppressive effects on key pathogenic processes. The novel oxidative changes in S100 proteins may lead to new diagnostic reagents and new strategies for therapy. Results will open new frontiers in asthma biology and will apply to other chronic inflammatory diseases.