SERPINB2 IS AN INDUCIBLE HOST FACTOR INVOLVED IN ENHANCING HIV-1 TRANSCRIPTION AND REPLICATION

SerpinB 2是炎症部位最丰富的蛋白质之一。我们已经证明，HIV-1感染也诱导SerpinB 2，SerpinB 2然后帮助病毒复制。在这项资助中，我们试图了解病毒如何导致这种蛋白质的产生，以及这种蛋白质如何增加病毒的复制。在人类中，有不同形式的SerpinB 2，这项资助旨在确定这些不同形式是否会以不同方式影响HIV-1复制。例如，具有某种形式的SerpinB 2的个体可能在HIV-1感染后较不易感染AIDS。

SerpinB2 is one of the most abundant proteins made at sites of inflammation. We have shown that HIV-1 infection also induces SerpinB2 and that SerpinB2 then helps the virus to replicate. In this grant we seek to understand how the virus causes this protein to be made and how this protein then increases virus replication. In the human population there are different forms of SerpinB2 and this grant seeks to determine whether these different forms affect HIV-1 replications differently. It may for instance be possible that an individual who has a certain form of SerpinB2 may be less susceptable to AIDS following HIV-1 infection.