The function and regulation of myogenic progenitor populations in aging and exercise

衰老与骨骼肌质量和力量的损失有关，这被统称为肌肉减少症。 肌肉减少症的常见后果包括由于福尔斯而导致的骨折、丧失独立性和制度化，最终导致生活质量降低。 尽管有许多关于肌肉减少症的基本机制的理论，但没有一个是完全可以接受的或解释肌肉减少症过程的所有方面。骨骼肌是一种独特的组织，与具有制造新肌肉能力的细胞（卫星细胞和干细胞）群体相关。 骨骼肌质量的维持依赖于这些细胞在整个生命过程中的持续运作。 我的研究计划建议检查卫星细胞和干细胞的丰度与衰老以及控制卫星细胞和干细胞功能的调控途径，因为我相信这些肌源性祖细胞群体可能是年龄相关性肌肉减少症的基本机制的组成部分。 此外，为了更好地了解可能影响卫星和干细胞调节途径的信号，我的研究计划将研究老年人的运动训练，作为维持有效卫星细胞和干细胞功能的策略。 我们将确定保持这些细胞功能所需的机制是否在衰老过程中得到维持，如果不是，那么在衰老过程中到底出了什么问题。 .最终，提高生活质量，延长独立生活是我们老龄化人口的目标。 我的研究计划旨在揭开骨骼肌衰老的奥秘，并为其他人提供方向（通过提供有趣的分子，细胞和生化数据），以扩展这些结果，用于开发与年龄相关的肌肉减少症的对策。

Aging is associated with a loss of skeletal muscle mass, and strength, which is collectively referred to as sarcopenia.  Common consequences of sarcopenia include bone fractures due to falls, a loss of independence and institutionalization, ultimately leading to a reduced quality of life.  Despite many theories regarding the fundamental mechanism(s) underlying sarcopenia, none is entirely acceptable or explains all aspects of the sarcopenic process. Skeletal muscle is a unique tissue that is associated with a population of cells (satellite cells and stem cells) with the ability to make new muscle.  The maintenance of skeletal muscle mass is dependent on the sustained operation of these cells throughout life.  My research program proposes to examine the abundance of satellite cell and stem cells with aging as well as the regulatory pathways that govern satellite cell and stem cell function, as I believe that these myogenic progenitor populations may be a component of the fundamental mechanism(s) of age-related sarcopenia.  In addition, to better understand the signals that may influence satellite and stem cell regulatory pathways my research program will examine exercise training in older adults as a strategy to maintain efficient satellite cell and stem cell function.  We will identify whether the machinery necessary to keep these cells functioning is maintained during aging, and if not, what exactly is going wrong during the aging process.  . Ultimately, improved quality of life, with prolonged independent living is the goal for our aging population.  My research program is aimed at unraveling the mysteries of skeletal muscle aging, and providing others with the direction (by providing intriguing molecular, cellular, and biochemical data) to extend these results for the development of countermeasures for age-related sarcopenia.