Characterization of drug disposition in skeletal tissues - a forensic context

在许多臭名昭著的死亡调查中，被调查的遗体已经腐烂到部分或完全腐烂的程度。在这种情况下，阐明药物或毒药在导致死亡或与死亡有关的事件中的作用是极其具有挑战性的。通常对血液或尿液等液体或肝脏等组织进行的常规毒理学分析通常是不可能的。在这些情况下，骨骼组织（矿化骨和/或骨髓）的分析可能是唯一剩下的选择。 该研究计划将通过在法医背景下表征骨骼组织中的药物浓度来解决这个问题。

In many notorious death investigations, the remains under investigation have decomposed to the point of partial or complete skeletonization. In such cases, elucidating the role of drugs or poisons in the events leading up to or associated with the death is extremely challenging. Conventional toxicological analyses, usually done on fluids such as blood or urine, or tissues such as liver, are often not possible. In these cases, analysis of skeletal tissues (mineralized bone and/or bone marrow) may be the only remaining option. This research program will address this problem through characterization of drug concentrations in skeletal tissues in a forensic context.