Somatic genomic alterations as predictors of clinical outcomes and benefit from chemohormonal therapy in metastatic hormone sensitive prostate cancer

该项目旨在通过分析前列腺癌患者的肿瘤基因，更深入地了解晚期和致死性前列腺癌的驱动生物学。通过这样做，我们将能够确定在侵袭性前列腺癌中发生的基因突变，以及它们如何影响对治疗的反应和临床结果。将来，我们或许可以将这些信息整合起来，为患者提供更明智、更“精确”的护理。

This projects seeks to achieve deeper understanding of the driving biology of advanced and lethal prostate cancer by way of profiling the tumor genes of patients with the disease. By doing so, we will be able to identify the gene mutations that occur in aggressive prostate cancer and how they influence response to treatment and clinical outcomes. We may be able to incorporate this information to deliver more informed, ‘precision’ care to patients in the future.