Sortilin forms a complex with APP and BACE to regulate Abeta production
Sortilin forms a complex with APP and BACE to regulate Abeta production
Sortilin 与 APP 和 BACE 形成复合物来调节 Abeta 的产生
批准号：
nhmrc : 1037776
负责人：
Dr Jia Liu
金额：
$13.93万
依托单位国家：
澳大利亚
项目类别：
Early Career Fellowships
财政年份：
2012
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2012-01-01 至 2014-12-31
中文摘要
翻译
阿尔茨海默病是一种神经退行性疾病，在老年人群中非常普遍。β淀粉样蛋白是一种毒性肽，来源于其前体淀粉样前体蛋白（APP）的代谢加工。该项目将研究一种名为sortilin的新型蛋白质如何与APP及其加工酶相互作用，以及如何产生有毒肽。了解APP和β-分泌酶的贩运？BACE？由分拣蛋白调节的蛋白质可能有助于了解阿尔茨海默病是如何发展的。
英文摘要
Alzheimer's disease is a neurodegenerative disorder which is highly prevalent in aging population. Amyloid beta is a toxic peptide derived from a metabolic processing of its precursor amyloid precursor protein (APP). This project will examine how a novel protein called sortilin interacts with APP and its processing enzyme and how the toxic peptide is produced. Understanding the trafficking of APP and beta-secretase ?BACE? regulated by sortilin may help understanding how Alzheimer's disease is developed.
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