Dissecting the heterogeniety of human tissue-resident memory T cells

组织驻留记忆T细胞（TRM）是免疫保护对抗感染和癌症的关键，但功能失调的TRM会导致自身免疫性疾病。虽然我们对TRM的大部分理解来自动物模型，但这些细胞在人类中如何工作在很大程度上是未知的。该项目旨在使用独特的人类器官供体组织资源来定义人类TRM子集在器官（如肠道，肝脏和皮肤）中的表型，功能和调节异质性。预期的成果是产生基础性的新知识，这将对开发对抗传染病、癌症和自身免疫的新疗法具有重要意义。

Tissue-resident memory T cells (TRM) are key to immune protection against infection and cancer, yet dysfunctional TRM cause autoimmune disease. Whilst much of our understanding of TRM comes from animal models, how these cells work in humans is largely unknown. This project aims to define the phenotypic, functional and regulatory heterogeneity of human TRM subsets in organs like the gut, liver, and skin using a unique human organ donor tissue resource. The expected outcomes are to generate fundamental new knowledge that will have significance for the development of new therapies against infectious diseases, cancer and autoimmunity.