A structural investigation into the T-cell response to Epstein Barr Virus infection

x射线晶体学是研究蛋白质三维结构的重要工具。蛋白质控制着细胞内的生物过程，正是蛋白质的精确形状决定了它们的功能。根据氨基酸的特定序列，蛋白质分子弯曲并形成独特而复杂的形状，氨基酸是蛋白质的所谓构建单元。这种特定的三维形状使蛋白质能够承担其特定的功能，例如与其他蛋白质结合，充当酶或与核酸相互作用。为了确定蛋白质的作用方式，在原子水平上了解其精确的三维形状是至关重要的。这一建议涉及了解控制对爱泼斯坦巴尔病毒免疫反应的蛋白质的精确形状。爱泼斯坦·巴尔病毒是一种普遍存在的人类病原体，与许多癌症有关。这项工作将进一步加深我们对爱泼斯坦·巴尔病毒免疫反应的理解。

X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as binding to other proteins, acting as an enzyme or interacting with nucleic acids. To determine how a protein acts, it is vital to know the precise three-dimensional shape at the atomic level. This proposal is concerned with understanding the precise shape of proteins that control the immune response to Epstein Barr Virus. Epstein Barr Virus is an ubiquitous human pathogen that has being linked to a number of cancers. This work will further our understanding of the immune response to Epstein Barr Virus.