Structure and biophysical analysis aided design of novel toxoid vaccines for a major class of bacterial toxins.

破伤风疫苗等灭活细菌毒素(类毒素)是安全有效的疫苗。胆固醇依赖型细胞溶血素(CDCs)是由A组链球菌(GAS)和肺炎球菌等多种人类重要病原体产生的细菌毒素。GAS没有可用的疫苗，肺炎球菌也没有通用疫苗。我们基于对CDC如何靶向人类细胞的新知识，开发了一种新的灭活CDC的方法，并将利用这一知识制造新的疫苗。

Inactivated bacterial toxins (toxoids), such as the tetanus vaccine, are safe and effective vaccines. Cholesterol dependent cytolysins (CDCs) are bacterial toxins produced by many important human pathogens including Group A Streptococcus (GAS) and Pneumococcus. GAS has no available vaccine and Pneumococcus does not have a universal vaccine. We have developed a new way of inactivating CDCs based on new knowledge of how they target human cells and will use this knowledge to make new vaccines.