Systems approaches to understanding mitochondrial function and dysfunction in disease

线粒体为我们的身体提供能量。这一过程中的缺陷会导致线粒体疾病，影响至少1/4300人。诊断往往是不确定的，几乎没有有效的治疗方法。最先进的CRISPR基因编辑工具将被用来制作模仿不同类型线粒体疾病的疾病模型。这些将被用来了解线粒体的功能，识别新的疾病基因，并开发新药。

Mitochondria produce the energy for our bodies. Defects in this process cause mitochondrial disease, which affects at least 1/4300 people. Diagnosis is often inconclusive and few if any effective treatments exist. State of the art CRISPR gene-editing tools will be used to make disease models mimicking the different types of mitochondrial disease. These will be used to understand how mitochondria function, identify new disease genes and develop new drugs.