Bioreactor systems design for bioprocess innovations

这个正在进行的研究计划培养学生的生物加工技能，这是加拿大工业和学术界的需求。这些技能是有效设计和控制生物技术业务所必需的。同时，该研究还探索了生产药物和其他生物制品的新方法。在本提案中，我们计划利用我们在发酵系统方面的丰富经验，研究适用于生产模型蛋白质产品（如治疗剂中发现的）和酶产品（如用于从纤维素材料中制备糖）的生物加工策略。除了基本知识的创造，第一个应用程序是感兴趣的制药业和第二个是相关的生物精炼厂的基础上可再生的生物质资源。根据我们的主张，在这些应用中，离心搅拌生物反应器装置在节能和污染风险较小方面比传统机械搅拌生物反应器装置具有明显的优势。这些因素在以前的工作中被忽略了。

This ongoing research program trains students in bioprocessing skills which are in demand by Canadian industry and academia. These skills are needed for the efficient design and control of biotechnology operations. Concurrently, the research explores new methods for producing pharmaceuticals and other biological products. In this proposal, we plan to use our extensive experience with fermentation systems to investigate bioprocessing strategies appropriate for production of a model protein product, such as found in therapeutic agents, and an enzyme product, such as used to make sugar from cellulosic materials. In addition to basic knowledge creation, the first application is of interest to the pharmaceutical industry and the second one is relevant to biorefineries that operate based on renewable biomass resources. According to our proposition, pneumatically-stirred bioreactor devices have distinct advantages over traditional mechanically-stirred ones for these applications in terms of energy conservation and less risk for contamination. These factors have been overlooked in previous work.