Targeting a bacterial glyco-Achilles heel to make new vaccines for Haemophilus influenzae and Neisseria gonorrhoeae.

引起淋病(淋病)、中耳感染和慢性阻塞性肺疾病恶化(流感嗜血杆菌)的细菌已经产生了多重抗药性。这些疾病是一个主要的健康和经济负担。在缺乏新药的情况下，预防这些疾病的疫苗已成为人类健康中一个尚未得到满足的主要需求。在这笔赠款中，我们将开发一种新的疫苗，针对一种我们已经发现是这些细菌的致命弱点的细菌特有的糖。

The bacteria that cause gonorrhoea (N. gonorrhoeae), middle ear infections and exacerbations of chronic obstructive lung disease (H. influenzae) have become multi-drug resistant. These diseases are a major health and economic burden. In the absence of new drugs, a vaccine to prevent these diseases has emerged as a major unmet need in human health. In this grant, we will develop a new vaccine that targets a bacterial-specific sugar that we have discovered is the Achilles heel of these bacteria.