Targeting bone marrow mediated angiogenesis and metastasis in breast cancer

尽管在治疗和诊断方面取得了进展，但乳腺癌仍然是妇女死亡的主要原因之一。转移和肿瘤血管募集是相关的。Mellick博士和其他人的工作表明，宿主骨髓为肿瘤血管系统提供内皮祖细胞（EPCs）。将EPC与肿瘤血管区分开的趋化因子及其受体将在肿瘤细胞和EPC祖细胞中被敲低，目的是防止肿瘤扩散。

Despite advances in treatment and diagnostics breast cancer (BC) remains one of the leading causes of death in women. Metastases and tumour blood vessel recruitment are linked. Work by Dr Mellick and others has shown that host bone marrow contributes endothelial progenitor cells (EPCs) to tumour vasculature. The chemokines and their receptors, which differentiate EPCs from tumour vessels, will be knocked down in the tumour cells and EPC progenitors with the aim of preventing tumour spread.