Targeting CD4-positive cells for anti-HIV gene therapy

艾滋病毒感染后的早期治疗被认为对最大限度地提高患者的生活质量非常重要。传统疗法在早期干预方面取得了一些成功，但耐药性总是会出现。该应用程序提出了一种基因治疗方法，通过向携带病毒的细胞中引入自杀基因来消除HIV感染细胞。这种方法的优点是与基因疗法相关的毒性有限，以及靶向特定细胞类型的能力。有人建议对一种腺病毒株进行基因修饰，以引入一种基因，该基因可以杀死它感染的同时含有HIV的细胞。这是一种新颖的方法，可能在未来成为一种重要的治疗方法。除了更传统的治疗方法外，抗hiv基因治疗也可能有用。

Treatment of HIV early following infection is thought to be important for maximising the quality of life of patients. Conventional therapy has had some success in early intervention but resistance invariably develops. This application proposes to develop a gene therapy approach to elimiate HIV infected cells by introducing a suicide gene into those cells that harbor the virus. The advantage of this approach is the limited toxicity that is associated with gene therapies as well as the ability to target specific cell-types. It is proposed to genetically modify a strain of adenovirus to introduce a gene that will kill cells that it infects that also contain HIV. This is a novel approach and potentially may be an important treatment in the future. Anti-HIV gene therapy may also be useful in addition to the more conventional treatments.