Targeting the Oncoprotein MDMX as a Novel Treatment for Triple Negative Breast Cancer

乳腺癌（BrCa）是全世界妇女癌症死亡的主要原因。不能对目前的治疗做出反应的brca会有最坏的结果。基于我们的新发现，我们提出了一种治疗这些癌症的新策略。我们的两个蛋白质目标是：(1)MDMX，我们发现它与BrCa的伴侣一起驱动；(2)突变p53，导致癌症扩散。我们计划直接针对这些侵略性BrCas的驱动因素，使用在许多癌症的试验中单独显示出巨大希望的新药

Breast cancer (BrCa) is a leading cause of cancer death in women worldwide. BrCas unable to respond to current therapies have the worst outcomes. We propose a novel strategy to treat these cancers, based on our new findings. Our two protein targets are: (1) MDMX, that we found drives BrCa with its partner, (2) mutant p53, which causes cancer spread. We plan to directly target these drivers of aggressive BrCas, using new drugs that individually show great promise in trials in a number of cance