Targeting oxidant-dependent pathways to treat skeletal muscle wasting in COPD

慢性阻塞性肺疾病（COPD）是一种主要的不可治愈的全球健康负担，是全球第四大死亡原因。相当大比例的COPD患者具有骨骼肌消耗和力量损失，这严重影响了他们的生活质量和生存。其原因尚不清楚，因此本研究的目的是确定COPD中骨骼肌萎缩是如何发生的，然后开发新的药物来治疗COPD中骨骼肌萎缩和功能障碍。

Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th largest cause of death worldwide. A significant proportion of COPD patients have skeletal muscle wasting and loss of strength which severely impacts on their quality of life and survival. The reason for this is unknown so the aim of this study is to determine how skeletal muscle wasting occurs in COPD and to then develop new medicines to treat skeletal muscle wasting and dysfunction in COPD.