Targeting Post-translational Modifications in TRPV Pain Channels

与辣椒的辛辣成分（TRPV1）结合的神经受体是我们疼痛通路的重要组成部分。TRPV1也对疼痛的热和酸有反应。慢性疼痛是一种重要的未满足的医疗需求，它使用TRPV1通路。在被辣椒激活后，神经中的反馈系统使TRPV1失活并停止疼痛信号。这种反馈在慢性疼痛中发生变化。本项目旨在了解和利用这种反馈机制，以找到新的方法来治疗疼痛。

The same nerve receptor that binds the pungent component of chilli peppers (TRPV1) is an important part of our pain pathway. TRPV1 also responds to painful heat and acids. Chronic pain is an important unmet medical need and it uses the TRPV1 pathway. After activation by chilli, a feedback system in nerves inactivates TRPV1 and stops pain signalling. This feedback changes in chronic pain. This project aims to understand and exploit this feedback mechanism to find new approaches to pain therapy.