Understanding the cause of Alzheimer's disease
Understanding the cause of Alzheimer's disease
批准号:
nhmrc : 1020843
负责人:
Prof David Small
金额:
$0.0万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2012-12-31
中文摘要
在本申请中概述的研究试图检查钙在AD发病机制中的作用。它将检验这样一种假设,即一种名为Abeta的蛋白质的积聚会导致大脑神经细胞中钙水平的增加。这种钙的增加可能会引发神经细胞损伤和痴呆症。这项研究的最终目的是确定治疗阿尔茨海默病的药物开发的新靶点。
英文摘要
The research outlined in this application seeks to examine the role of calcium in the pathogenesis of AD. It will examine the hypothesis that the build-up of a protein known as the Abeta causes an increase in levels of calcium in nerve cells of the brain. This increase in calcium may trigger nerve cell damage and dementia. The ultimate aim of the research is to identify new targets for drug development in Alzheimer's disease.
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专著(0)
科研奖励(0)
会议论文
Studies on the biochemistry and molecular biology of amyloidosis
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批准号:nhmrc : 1002473
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项目类别:Research Fellowships
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资助金额:$44.31万
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财政年份:2011
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负责人:Prof David Small
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依托单位:
Research Fellowship - Grant ID:334035
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批准号:nhmrc : 334035
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项目类别:NHMRC Research Fellowships
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资助金额:$54.12万
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财政年份:2005
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负责人:Prof David Small
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依托单位:
Cholinergic abnormalities in Alzheimer's disease: identification of novel therapeutic targets
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批准号:nhmrc : 284236
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项目类别:NHMRC Project Grants
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资助金额:$31.91万
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财政年份:2004
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负责人:Prof David Small
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依托单位:
Functional studies on a neuroprotective activity of the amyloid precursor protein of Alzheimer s disease.
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批准号:nhmrc : 145761
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项目类别:NHMRC Project Grants
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资助金额:$10.7万
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财政年份:2001
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负责人:Prof David Small
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依托单位:
Ongoing Uncoupled Research Fellowship
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批准号:nhmrc : 170223
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项目类别:NHMRC Research Fellowships
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资助金额:$27.49万
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财政年份:2001
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负责人:Prof David Small
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依托单位:
Extracellular matrix, cell-surface receptors and Alzheimer's disease: a novel glycoform of acetylcholinesterase
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批准号:nhmrc : 114170
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项目类别:NHMRC Project Grants
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资助金额:$17.68万
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财政年份:2000
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负责人:Prof David Small
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依托单位:
海外基金