Understanding and Controlling Influenza

虽然目前的流感疫苗抑制了冬季流行，但它们必须经常更新，以跟上病毒的变异，而且它们无法预防由新的流感病毒(如禽流感)引起的大流行。该程序将定义流感病毒如何与免疫系统相互作用，以产生免疫，特别是由“杀手”T细胞介导的免疫。我们将利用这些知识来开发和评估诱导长期T细胞免疫的疫苗，这种疫苗可以预防季节性流感和大流行流感。

While current influenza vaccines blunt winter epidemics, they must be updated frequently to keep up with virus mutation and they do not protect against pandemics caused by new flu viruses (such as bird flu). This program will define how flu virus interacts with the immune system to generate immunity mediated particularly by “killer” T cells. We will use this knowledge to develop and evaluate vaccines that induce long-lasting T-cell immunity that can protect against both seasonal and pandemic flu.