Understanding and controlling thrombus formation

人类循环中的血小板的快速相互作用对预防出血至关重要，但也可能导致血栓性疾病(心脏病发作、中风)。这些高度受调控的相互作用涉及特定的黏附蛋白。我们的研究将确定调节血小板相互作用的因素。血栓形成过程的成像将以前所未有的分辨率量化血小板功能，我们有一组新的候选试剂将接受抗血栓潜力的评估。

The rapid interactions of circulating human blood platelets is critical to prevent bleeding, but can cause thrombotic diseases (heart attack, stroke). These highly regulated interactions involve specific adhesive proteins. Our studies will define factors regulating platelet interactions. Imaging the thrombotic process will quantify platelet function at an unprecedented resolution and we have a panel of new candidate reagents that will be assessed for antithrombotic potential.