Understanding influenza-specific T cell immunity in the Indigenous and non-Indigenous populations

土著人口中流感的住院率和死亡率很高。目前迫切需要一针通用疫苗，以防止季节性和大流行性菌株。为了确定潜在的疫苗靶点，我们首先必须确定哪些病毒蛋白质将诱导大的保护性免疫应答。这些反应因种族而异，因此将在土著和非土著澳大利亚人之间进行比较，以确定对不同种族具有保护作用的多种候选疫苗。

Hospitalisation and mortality rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. To identify potential vaccine targets we firstly have to determine which viral proteins will induce a large protective immune response. These responses vary between ethnicities thus comparisons will be drawn between Indigenous and non-Indigenous Australians to determine multiple vaccine candidates that will be protective across ethnicities.