Identification and characterisation of HLA-E restricted influenza A virus-specific CD8+ T cells

HLA-E 限制性甲型流感病毒特异性 CD8 T 细胞的鉴定和表征

• 批准号: nhmrc : 1110429
• 负责人: Dr Emma Grant
• 金额: $ 24.47万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterisation-hla-t-cells/663132
• 关键词: Identification; characterisation; HLA; restricted; influenza

With seasonal epidemics and the continual threat of a pandemic, there is an urgent need for a one-shot universal vaccine that protects against different influenza strains. This can potentially be achieved by the activation of killer T cells. I will identify new virus targets presented by a highly conserved human protein. Killer T cell recognition of these targets may provide a unique opportunity to develop an improved vaccine.

由于季节性流行和大流行的持续威胁，迫切需要一种可预防不同流感毒株的一次性通用疫苗。这有可能通过激活杀伤性 T 细胞来实现。我将识别由高度保守的人类蛋白质呈现的新病毒靶标。杀伤性 T 细胞对这些靶标的识别可能为开发改进的疫苗提供独特的机会。