Identification and characterisation of HLA-E restricted influenza A virus-specific CD8+ T cells

HLA-E 限制性甲型流感病毒特异性 CD8 T 细胞的鉴定和表征

• 批准号: nhmrc : GNT1110429
• 负责人: Dr Emma Grant
• 金额: $ 35.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterisation-hla-t-cells/1346731
• 关键词: Identification; characterisation; HLA; restricted; influenza

With seasonal epidemics and the continual threat of a pandemic, there is an urgent need for a one-shot universal vaccine that protects against different influenza strains. This can potentially be achieved by the activation of killer T cells. I will identify new virus targets presented by a highly conserved human protein. Killer T cell recognition of these targets may provide a unique opportunity to develop an improved vaccine.

随着季节性流行和大流行的持续威胁，迫切需要一种一次性通用疫苗来预防不同的流感病毒株。这可能是通过激活杀伤T细胞来实现的。我将识别由高度保守的人类蛋白质呈现的新病毒靶点。杀手T细胞对这些靶点的识别可能会为开发改进的疫苗提供一个独特的机会。