Understanding the Interplay Between ER Stress and Inflammation

成千上万的澳大利亚人患有肠道和肺部的慢性炎症性疾病。我们已经确定了炎症如何引起一种压力，导致细胞中蛋白质合成异常，从而形成微生物屏障。感染后，这一过程可能引发慢性炎症性疾病。我们在这个项目中寻求的对这一过程的进一步理解可能会导致治疗常见炎症性疾病的新方法。

Chronic inflammatory diseases in the gut and lung affect hundreds of thousands of Australians. We have identified how inflammation causes a type of stress resulting in abnormal protein synthesis in the cells which make the barrier to microbes. Following an infection this process might be the trigger for chronic unresolving inflammatory disease. The further understanding of this process we seek in this project is likely to lead new approaches to treat common inflammatory diseases.