UNDERSTANDING THE MOLECULAR MECHANISMS CONTROLLING NUCLEOLAR SURVEILLANCE IN DISEASE

细胞制造核糖体（制造蛋白质的细胞工厂）的能力发生改变，会导致一系列疾病，包括癌症和一类被称为核糖体病的遗传性疾病，这种疾病很少见，但在很大程度上无法治愈。这些变化通过控制导致细胞停止分裂或死亡的“核仁监视途径”而引起疾病。在这里，我们建议鉴定调节这一途径的新基因，以确定治疗这些疾病的新靶点。

Alterations in the ability of cells to make ribosomes, the cellular factories that make protein, contribute to a range of diseases including cancer and a class of inherited disorders called ribosomopathies that are rare but largely untreatable. These changes cause disease by controlling the “nucleolar surveillance pathway” that causes cells to either stop dividing or die. Here we propose to identify new genes that regulate this pathway to identify new targets for treating these diseases.