The Use of a Multidrug Pill in Reducing Cardiovascular Events (UMPIRE) trial

患有心血管疾病的患者患心脏病或中风的风险非常高，目前的指南建议这些患者长期使用阿司匹林、降血压药物和降胆固醇药物来降低风险。这项拟议的研究将调查复方药丸（一种含有所有这些药物的药丸）的可用性是否有助于确保患者得到适当的这些治疗，并长期服用。澳大利亚研究人员将在收集和解释这项试验的数据方面发挥关键作用。此外，澳大利亚的研究人员将把这项研究的结果与澳大利亚（1600名患者，包括600名土著参与者）和新西兰（600名患者，包括600名毛利人参与者）进行的类似试验的结果结合起来。这篇综述将提供非常准确的信息，关于复方药丸的有效性，以及如何在全球范围内使用。

Patients who have cardiovascular disease are at very high risk of experiencing a heart attack or stroke, and current guidelines recommend the long-term use of aspirin, blood pressure lowering drugs and a cholesterol lowering drug in such patients to reduce their risks. The proposed research will investigate whether the availability of a polypill (a single pill containing all these drugs) will help ensure patients are appropriately prescribed these treatments, and keep taking them long-term. Australian researchers will have a pivotal role in collecting and interpreting the data in this trial. In addition, Australian researchers will combine the findings of this study with results from similar trials being conducted in Australia (1600 patients, including 600 Aboriginal participants) and New Zealand (600 patients, including 600 Maori participants). This overview will provide very accurate information about the usefulness of the polypill, and how it should be used worldwide.