Ambulatory cardiovascular monitoring

将获得一套动态数据采集设备，以研究正常日常生活功能以及受控实验室条件下的心血管控制。随着动脉血压，血流速度和组织氧合的动态监测，我们将启动新的研究领域，扩大我们在心血管动力学研究的现有专业知识。设备的性质还确保它将用于标准实验室条件以及流动调查。我们率先使用超声成像和多普勒超声血流速度测量，在受控的实验室条件下，在休息到运动过渡期间量化整个腿部或前臂肌肉血流。现在，我们提出开发技术，将允许量化脑和肌肉血流和组织氧合沿着与连续动脉血压下的动态条件下的日常生活：从床上或椅子上，站立，行走或攀登的步骤。我们继续进行，在受控条件下与栓系设备，研究从仰卧休息（有或没有事先卧床休息或从国际空间站返回的宇航员）的过渡，我们知道，仰卧到坐姿，或坐姿到站立姿势的简单过渡会导致动脉血压和脑血流速度的短暂下降。我们还不知道的是，在正常过渡到日常生活活动时，血压、脑血流速度和氧合会发生什么变化。我们将研究机制负责低血压的立场。我们将研究脑血流量和氧合与日常生活活动的变化，重点是为什么定期锻炼可能会增加脑血流量，从而可能有益于老年人的认知功能。总的来说，这些数据将提供关于血压，流量和大脑或运动肌肉的氧合之间相互关系的新信息。

A suite of ambulatory data acquisition devices will be acquired to study cardiovascular control under normal functions of daily life as well as in controlled laboratory conditions. With ambulatory monitors of arterial blood pressure, blood flow velocity and tissue oxygenation, we will initiate new research areas that expand on our existing expertise in studies of cardiovascular dynamics. The nature of the equipment also insures that it will be used in standard laboratory conditions as well as ambulatory investigations. We pioneered the use of ultrasound imaging and Doppler ultrasound blood flow velocity measurements to quantify whole leg or forearm muscle blood flow during rest to exercise transitions under controlled laboratory conditions. Now we propose developing techniques that will permit quantification of brain and muscle blood flow and tissue oxygenation along with continuous arterial blood pressure under dynamic conditions of daily life: rising from bed or a chair, standing, walking or climbing steps. We continue to conduct, under controlled conditions with tethered equipment, studies of transitions from supine rest (with or without prior bed rest or in astronauts returning from the International Space Station), and we know that the simple transition of supine to seated, or of seated to standing positions causes a transient drop in arterial blood pressure and cerebral blood flow velocity. What we do not yet know is what happens to blood pressure, brain blood flow velocity and oxygenation with normal transitions to activities of daily life. We will examine mechanisms responsible for low blood pressure on standing. We will examine changes in brain blood flow and oxygenation with activities of daily life with a focus on why regular exercise might increase brain blood flow potentially benefiting cognitive function in an aging population. Overall, these data will provide novel information on the inter-relationships between blood pressure, flow and oxygenation to the brain or exercising muscles.