Spatio-temporal simultaneous measurements of neurophysiological and hemodynamics signals using dual methods of optical imaging

本申请中要求的设备是一种快速相机系统，该系统使用特殊解决方案优化用于大脑的光学成像。溶液的分子粘附在大脑中的细胞上，并发出随着这些细胞活动的变化而变化的光。所要求的系统将与现有的能够对大脑中的血流进行成像的摄像系统相结合。这一组合将创造出第一个能够同时记录血液信号和大脑活动的成像系统。这个新的系统将支持几个研究项目，所有这些项目都是在理解大脑活动和大脑中的血流如何相互作用的领域。一个程序试图在静止状态下理解这种关系，当没有感官刺激或任务呈现给受试者时。第二个项目研究不同类型的细胞在协调大脑活动和血液流动之间的相互作用中的作用。第三个项目将使用该系统来研究EEG脑电波如何与血液信号相关。第四个项目将使用该系统获得的数据测试现有的大脑活动和血流之间相互作用的数学模型。

The equipment requested in this application is a fast camera system optimized for optical imaging of the brain using special solutions. The molecules of the solutions adhere to the cells in the brain, and emanate light that changes with changes in activity of these cells. The requested system will be combined with an already existing camera system that is capable of imaging blood flow in the brain. This combination will create the first imaging system capable of recording blood signals and brain activity simultaneously. This novel system will support several research programs, all of which are in the field of understanding how brain activity and blood flow in the brain interact. One program seeks to understand this relation under resting condition, when no sensory stimuli or tasks are presented to the subject. A second program investigates the role of different cell types in coordinating the interaction between brain activity and blood flow. A third program will use the system in order to investigate how EEG brain waves are related to blood signals. The fourth program will test existing mathematical models of the interaction between brain activity and blood flow using data obtained by the system.