A cost and environmentally effective rapid evaporator as a key component of a combinatorial synthesis facility for the generation of new types of bioactive small molecules.

化学生物学和药物化学的进步在很大程度上依赖于高纯度新型小分子的可获得性和快速获得。为响应这些需求，组合化学和微波化学等现代技术应运而生，以加速和促进新型有机化合物的提纯。2004年，我系成立了专门的组合合成实验室。这个现代化的实验室为化学生物学和药物化学的研究人员提供支持。为了生产大量的小分子，这个设施需要一系列仪器，所有这些都必须保持良好的秩序，以避免延误。目前用于样品合成和层析纯化后快速蒸发的快速蒸发器已经广泛使用了十多年。这台机器需要更换，因为它最近被诊断出有不可修复的缺陷。它泄漏制冷剂气体的速度需要每3个月补充一次。这种情况代价高昂，在环境上不可接受。为了保持该设施的生产率，并避免我们与几位生物科学家正在进行的药物化学合作出现任何延误，我们请求为购买新的快速蒸发器提供资金。在我们的设施中已经发现了非常有前景的抗癌先导化合物，这种新的蒸发器将允许持续产生改进的库和类似物，而不会延迟。

Progress in chemical biology and medicinal chemistry relies extensively on the availability and rapid access to novel small molecules of high purity. In response to these demands, modern techniques such as combinatorial chemistry and microwave chemistry have been developed in order to accelerate and facilitate the purification of novel organic compounds. In 2004, our Department created a dedicated laboratory for combinatorial synthesis. This modern laboratory supports researchers in chemical biology and medicinal chemistry. To produce large collections of small molecules, this facility requires a chain of instrumentation, all of which must be in good order in order to avoid delays. The current rapid evaporator employed to quickly evaporate samples after synthesis and chromatographic purification has been used extensively for more than ten years. This unit needs replacement as it was recently diagnosed with a non-repairable defect. It leaks refrigerant gas at a rate requiring refills every 3 months. This situation is costly and environmentally unacceptable. To maintain the facility's productivity and avoid any delays in our ongoing medicinal chemistry collaborations with several biological scientists, we request funding for the purchase of a new rapid evaporator. Very promising anti-cancer lead compounds have been identified in our facility, and this new evaporator will allow the continuous generation of improved libraries and analogues with no delays.