Validation and Effect of Low Endothelial Shear Stress on Coronary Atherosclerosis

尽管在健康促进和治疗选择方面取得了进展，但心脏病仍然是一个主要问题。心脏病专家面临的一个主要挑战是识别疾病进展或心脏病发作风险最高的患者。这项提议涉及心脏病学家和工程师之间的合作，旨在评估由血流引起的机械应力是否可以通过心脏扫描可靠地计算出来，以及是否可以在临床上用于改善临床事件的预测。

Heart disease remains a major concern despite advances in health promotion and treatment options. A major challenge faced by cardiologists is identifying patients that are at highest risk of disease progression or heart attacks. This proposal involves collaboration between cardiologists and engineers, aiming to assess whether mechanical stress induced by blood flow can be reliably calculated from heart scans and if this can be used clinically to improve prediction of clinical events.