Elucidation of the biosynthesis of 4-hydroxy-2-alkylquinolines by pseudomonas aeruginosa
Elucidation of the biosynthesis of 4-hydroxy-2-alkylquinolines by pseudomonas aeruginosa
批准号:
38364-2007
负责人:
Lépine, François
金额:
$2.19万
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2010
资助国家:
加拿大
项目状态:
已结题
起止时间:
2010-01-01 至 2011-12-31
中文摘要
近年来,已经证明细菌之间在一种称为“群体感应”的过程中相互交流。在这种机制中,细菌分泌一个或多个信号分子,当它们在介质中获得特定浓度时,这些分子与相应的调节蛋白结合,从而增加信号化合物的产生,并激活其他毒力基因。在感染的早期阶段,这种同步行为的优势是等待细菌数量足够多,以便同时释放的毒力因子可以压倒宿主防御。
英文摘要
In recent years it has been demonstrated that bacteria communicate with one another, in a process called « Quorum Sensing ». In this mechanism, bacteria secrete one or many signalling molecules which, when they have reched a specific concentration in the medium, bind to their corresponding regulator protein that will increase the production of the signalling compounds and will also activate other virulence genes. During the early stage of an infection, the advantage of such synchronized behaviour is to wait until the number of bacteria is sufficiently large so that the simultaneous release of virulence factor could overwhelm the host defence.
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A new look at the biosynthesis of 4-hydroxy-2-alkylquinolines in Pseudomonas aeruginosa
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批准号:38364-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.04万
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财政年份:2016
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负责人:Lépine, François
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依托单位:
A new look at the biosynthesis of 4-hydroxy-2-alkylquinolines in Pseudomonas aeruginosa
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批准号:38364-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.04万
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财政年份:2015
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负责人:Lépine, François
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依托单位:
A new look at the biosynthesis of 4-hydroxy-2-alkylquinolines in Pseudomonas aeruginosa
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批准号:38364-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.04万
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财政年份:2014
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负责人:Lépine, François
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依托单位:
A new look at the biosynthesis of 4-hydroxy-2-alkylquinolines in Pseudomonas aeruginosa
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批准号:38364-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.04万
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财政年份:2013
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负责人:Lépine, François
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依托单位:
A new look at the biosynthesis of 4-hydroxy-2-alkylquinolines in Pseudomonas aeruginosa
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批准号:38364-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.04万
-
财政年份:2012
-
负责人:Lépine, François
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依托单位:
Elucidation of the biosynthesis of 4-hydroxy-2-alkylquinolines by pseudomonas aeruginosa
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批准号:38364-2007
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2011
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负责人:Lépine, François
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依托单位:
A mass spectrometer for the analysis of microbial metabolites
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批准号:375651-2009
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项目类别:Research Tools and Instruments - Category 1 (<$150,000)
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资助金额:$9.28万
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财政年份:2009
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负责人:Lépine, François
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依托单位:
Elucidation of the biosynthesis of 4-hydroxy-2-alkylquinolines by pseudomonas aeruginosa
-
批准号:38364-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.19万
-
财政年份:2009
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负责人:Lépine, François
-
依托单位:
Elucidation of the biosynthesis of 4-hydroxy-2-alkylquinolines by pseudomonas aeruginosa
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批准号:38364-2007
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
-
财政年份:2008
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负责人:Lépine, François
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依托单位:
Elucidation of the biosynthesis of 4-hydroxy-2-alkylquinolines by pseudomonas aeruginosa
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批准号:38364-2007
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
-
财政年份:2007
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负责人:Lépine, François
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依托单位:
Study of the de novo metabolic pathways of rhamnolipids
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批准号:38364-2002
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2006
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负责人:Lépine, François
-
依托单位:
Study of the de novo metabolic pathways of rhamnolipids
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批准号:38364-2002
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项目类别:Discovery Grants Program - Individual
-
资助金额:$2.55万
-
财政年份:2005
-
负责人:Lépine, François
-
依托单位:
Study of the de novo metabolic pathways of rhamnolipids
-
批准号:38364-2002
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项目类别:Discovery Grants Program - Individual
-
资助金额:$2.55万
-
财政年份:2004
-
负责人:Lépine, François
-
依托单位:
Study of the de novo metabolic pathways of rhamnolipids
-
批准号:38364-2002
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.55万
-
财政年份:2003
-
负责人:Lépine, François
-
依托单位:
Study of the de novo metabolic pathways of rhamnolipids
-
批准号:38364-2002
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.55万
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财政年份:2002
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负责人:Lépine, François
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依托单位:
Collision-induced oxygen addition reactions for analysis of chlorinated xenobiotics in a triple quadrupole mass spectrometer
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批准号:38364-1998
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.26万
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财政年份:2001
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负责人:Lépine, François
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依托单位:
Collision-induced oxygen addition reactions for analysis of chlorinated xenobiotics in a triple quadrupole mass spectrometer
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批准号:38364-1998
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项目类别:Discovery Grants Program - Individual
-
资助金额:$1.26万
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财政年份:2000
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负责人:Lépine, François
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依托单位:
Purchase of a triple quadrupole mass spectrometer
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批准号:228481-2000
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项目类别:Research Tools and Instruments - Category 3 (>$325,000)
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资助金额:$9.98万
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财政年份:1999
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负责人:Lépine, François
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依托单位:
Collision-induced oxygen addition reactions for analysis of chlorinated xenobiotics in a triple quadrupole mass spectrometer
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批准号:38364-1998
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项目类别:Discovery Grants Program - Individual
-
资助金额:$1.26万
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财政年份:1999
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负责人:Lépine, François
-
依托单位:
Collision-induced oxygen addition reactions for analysis of chlorinated xenobiotics in a triple quadrupole mass spectrometer
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批准号:38364-1998
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.2万
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财政年份:1998
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负责人:Lépine, François
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依托单位:
国内基金
海外基金
中老年男性迟发性性腺功能障碍(LOH)分子生物学机制的研究
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批准号:30772285
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项目类别:面上项目
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资助金额:30.0万元
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批准年份:2007
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负责人:辛钟成
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依托单位: