New opportunities in domino reactions and homogenous gold(I) catalysis

开发形成碳-碳键的新的合成方法对于高效合成在医学、材料科学、生物燃料等方面具有重要应用的分子是至关重要的。此外，对可持续性的日益重视，对高效和最小限度地减少废物的过程的需要变得越来越重要。在这个计划中，我们将探索多米诺骨牌反应和金催化的新方向，将这些概念结合起来，开发出具有普遍适用性的强大方法来合成具有医学意义的重要分子。Au(I/III)络合物是选择性配位于p-体系的软Lewis酸，特别是炔烃和烯。因此，这使得底物p-体系缺乏电子，从而有利于亲核分子的加入。近年来，金的均相催化受到了科学界的极大关注。金催化在立体选择性合成中的应用在很大程度上被忽视。根据我们实验室的最新进展，我们将探索金的催化、多米诺反应及其在复杂天然产物全合成中的应用。

The development of new synthetic methods for the formation of carbon-carbon bonds is of paramount importance for the efficient synthesis of molecules having important application in medicine, material science, biofuels, etc. Furthermore, the ever-increasing emphasis being placed on sustainability, the need for efficient and waste-minimizing processes is becoming more and more important. In this proposal, we will investigate new directions in domino reactions and gold catalysis, merging these concepts for the development of powerful methods of general applicability for the synthesis of medicinally important molecules.Au(I/III) complexes are soft Lewis acids which selectively coordinate to p-systems, notably, alkynes and allenes. As a result, this makes the substrate p-system deficient in electrons thus favoring the addition of nucleophiles. In recent years, homogenous catalysis by gold has received considerable attention by the scientific community. Applications of gold catalysis in stereoselective synthesis have been largely overlooked. Based upon recent development in our laboratory, we will explore gold catalysis, domino reactions and their applications in total synthesis of complex natural products.