Distillers dried grains with solubles (DDGS) as a potential source of immunomodulatory and growth promoting activity for poultry

据估计，在不久的将来，加拿大的乙醇工厂每年将生产130万至140万吨玉米和小麦蒸馏干谷物（DDGS），用于动物和家禽饲养。为了从这些副产品中获得最大价值，必须向家禽业展示它们作为饲料原料的天然优势。DDGS是酿酒酵母（Saccharomyces cerevisiae）发酵的副产物，含有大量对肠道发育和健康有益的成分（即ß1,3-和ß1,6-葡聚糖、核苷酸、甘露聚糖低聚或多糖），并有效刺激免疫系统。本研究旨在探讨玉米和小麦为基础的DDGS与酿造和烘焙行业酵母为基础的DDGS对肉鸡胃肠道发育、免疫系统功能和生长性能的影响。外源性酶可以用来修改和增加活性碳水化合物成分的可用性引入鸟类的消化系统。这些补充剂的潜在协同效应和酶技术的使用将被研究。本研究的里程碑是：1。研究酵母产品中不同碳水化合物和核苷酸衍生物对先天免疫和获得性免疫的影响；采用产气荚膜梭菌致坏死性肠炎鸡模型，研究饲粮DDGS的免疫调节和促生长作用。本研究将有助于我们更好地了解DDGS副产物的营养价值，并将促进玉米和小麦DDGS这一加拿大重要饲料资源在家禽口粮中的有效利用。

It is estimated, that in the near future the ethanol plants in Canada will generate 1.3-1.4 million tonnes of corn and wheat distillers dried grains with solubles (DDGS) destined for animal and poultry feeding per year. In order to derive maximum value from these co-products, their natural advantage as feed ingredients must be presented to the poultry industry. DDGS are co-products of brewer's yeast (Saccharomyces cerevisiae) fermentation which contain significant quantities of components (i.e., ß1,3- and ß1,6-glucans, nucleotides, mannan oligo- or polysaccharides) beneficial for gut development and health, and effective in immune system stimulation. The objective of the proposed research is to investigate the effect of corn- and wheat-based DDGS vs. yeast-derived products of brewing and bakery industries on gastrointestinal tract development, immune system function and growth performance of broiler chickens. Exogenous enzyme can be used to modify and to increase availability of active carbohydrate components upon introduction to the bird's digestive system. Potential synergistic effect of these supplements and the use of enzyme technology will be investigated. The milestones of this research are: 1. To investigate the effect of different carbohydrates and nucleotides derivatives from yeast products on innate and acquired immunity, and 2. To determine the immunomodulating and growth promoting effect of dietary DDGS using the chicken model developed for inducing necrotic enteritis caused by Clostridium perfringens. This research will contribute to our better understanding of the nutritive value of DDGS co-products and will promote the use of corn and wheat DDGS, important Canadian feed resources, effectively in poultry rations.