Meiotic recombination in Neurospora crassa: a model for the process in humans and other multicellular eukaryotes

粗糙脉孢子虫减数分裂重组：人类和其他多细胞真核生物减数分裂重组过程的模型。在高等生物体的有性周期中，基因在减数分裂过程中通过重组进行改组。这一点在酵母中理解得最清楚。我们的研究结果表明，脉孢霉的重组不同于酵母的重组。它对序列错配的耐受性更强，基因转换和交换的相对频率不同，经常中断转换区域，并具有控制重组热点活动的调控基因。我们建议从基因上解剖脉孢子虫重组，这似乎是人类和其他高等真核生物中重组的更接近的模型，了解重组有助于控制遗传疾病、农业中的高效育种和我们对进化的理解。

Meiotic recombination in Neurospora crassa: a model for the process in humans and other multicellular eukaryotes. Genes are shuffled by recombination during meiosis in the sexual cycle of higher organisms. This is best understood in yeast. Our findings show Neurospora recombination differs from yeast recombination. It is more tolerant of sequence mismatch, differs in the relative frequencies of gene conversion and crossing over, has frequently interrupted conversion tracts and has transacting genes controlling recombination hotspot activity. We propose to genetically dissect Neurospora recombination which appears to be a closer model for recombination in humans and other higher eukaryotes, where understanding recombination can assist control of genetic disease, efficient breeding in agriculture and our understanding of evolution.