Amino Acid and Peptide Radicals in Biochemistry and Synthesis

氨基酸和肽自由基在生物化学和合成中的作用。本研究的目的是为了更好地了解肽和蛋白质的生化自由基反应，特别是涉及超氧自由基阴离子和硫醇的反应，以及酶催化反应中的肽自由基。通过这项工作获得的知识将用于合成具有生理活性的氨基酸和肽，以及建立调节生化自由基过程的方法。这项研究的最终目标是开发方法和药物化合物来预防和治疗与这些反应相关的人类疾病，并为肽和蛋白质生物材料的商业开发奠定基础。

Amino Acid and Peptide Radicals in Biochemistry and Synthesis. The aim of this research is to develop a better fundamental understanding of biochemical free radical reactions of peptides and proteins, particularly those involving superoxide radical anion and thiols, and peptide radicals in enzyme-catalysed reactions. Knowledge gained through this work will be used in the synthesis of physiologically active amino acids and peptides, as well as to establish ways to regulate biochemical free radical processes. The ultimate goal of the research is to develop methods and pharmaceutical compounds to prevent and treat human disorders associated with these reactions, and to underpin commercial exploitation of peptide and protein biomaterials.