Medicinal inorganic chemistry

我们实验室的研究项目研究金属离子在疾病的病因学，诊断和治疗中的作用。 这些项目包括各种金属离子，广泛的配体系统，全套技术和合作，以及各种财政支持来源。 有机配体和无机配合物的合成以及物理（电位滴定和分光光度滴定，EPR，电化学，NMR，MS等）和生物学研究。 这种方法的成功是即将进入双（乙基麦芽酚）氧钒（IV）（也称为BEOV或AKP-020）进入2型糖尿病的IIa期临床试验（www.akesis.com）-基础NSERC和CIHR资助的配位化学和药理学研究已经产生了临床研究药物和潜在的口服治疗。

Research projects in our labs study the roles of metal ions in the etiology, diagnosis, and therapy of disease. These projects encompass a variety of metal ions, broad spectrum of ligand systems, panoply of techniques and collaborations, and various sources of financial support. Synthesis of organic ligands and inorganic complexes as well as physical (potentiometric and spectrophotometric titrations, EPR, electrochemistry, NMR, MS etc.) and biological studies are undertaken in the research programme. The success of this approach is the imminent entry of bis(ethylmaltolato)oxovanadium(IV) (also known as BEOV or AKP-020) into a phase IIa clinical trial in type 2 diabetes (www.akesis.com) - basic NSERC- and CIHR-funded research in coordination chemistry and pharmacology has yielded a clinically studied drug and potential oral therapy.