Attachment of Growth Factors to Pure, Plasma Modified and Coated Titanium Substrates

生长因子与纯钛、等离子体改性钛和涂层钛基质的连接。钛及其合金通常用作医疗和牙科植入物。尽管有羟基磷灰石涂层，一种众所周知的改善植入物固定的材料，但许多这样的植入物由于缺乏与骨的牢固结合而失败。该提案旨在通过其表面改性和随后的生长因子附着来实现钛植入物的长期稳定性。后者的使用已被证明有助于骨-植入物整合。成功的项目实施将提供钛种植体表面，这将有助于实现更快和更好的种植体固定和长期稳定性。开发的知识，专业知识和技术将帮助行业合作伙伴扩大其研究基础和业务，并在澳大利亚创造财富。在新兴的生物技术领域培养世界一流的研究生将是另一项主要成果。

Attachment of Growth Factors to Pure, Plasma Modified and Coated Titanium Substrates. Titanium and its alloys are routinely used as medical and dental implants. Despite coating with hydroxyapatite, a material well known to improve implant fixation, many such implants fail because of lack of strong integration with bone. This proposal aims at achieving long-term stability of titanium implants through their surface modification and subsequent attachment of growth factors. The use of latter has already been shown to help bone-implant integration. Successful project implementation will provide titanium implant surfaces that will help achieve speedier and improved implant fixation with long-term stability. Knowledge, expertise and techniques developed will help the industry partner expanding its research base and business and generating wealth in Australia. Training of world-class research students in the emerging field of biotechnology will be another major outcome.