Australian Laureate Fellowships - Grant ID: FL210100107

追踪纳米粒子：从细胞培养到体内递送。了解细胞如何在活生物体的实时环境中发挥作用是细胞生物学新时代的关键挑战。使用超分辨率光学显微镜和最先进的相关电子显微镜以及模型系统，该奖学金旨在提供对自然环境中细胞的新理解。重要的是，该项目将阐明蛋白质或纳米颗粒如何从血液进入组织，然后进入细胞，并在此过程中提供急需的蛋白质和颗粒原位运输知识。其成果和好处包括将前沿基础科学引入细胞功能、教育、推广和澳大利亚在高需求技能方面的能力建设。

Tracking nanoparticles: from cell culture to in vivo delivery. Understanding how cells function in the ‘real-time’ context of a living organism is a key challenge in the new era of cell biology. Using super-resolution light microscopy and state-of-the-art correlative electron microscopy together with model systems, this Fellowship aims to deliver new understandings of cells in their natural environment. Significantly, the project will elucidate how proteins or nanoparticles pass from the bloodstream into tissues and then into cells, and in doing so deliver much-needed knowledge of protein and particle trafficking in situ. Outcomes and benefits include leading-edge fundamental science into the function of cells, education, outreach and building of Australian capacity in high-demand skill sets.