Instantaneous deposition rate of aerosols in the lung

气雾剂药物递送与个体患者的呼吸模式的协调是开发下一代智能气雾剂递送装置的最大挑战之一。精确的数值模拟气溶胶沉积是至关重要的优化设计和开发这些新的设备。现有的沉积模型不能捕捉到瞬态呼吸模式的影响，不能预测随时间变化的局部沉积速率。本项目的目标是开发新的沉积函数的瞬时，瞬时沉积速率的气溶胶粒子。

The coordination of aerosol drug delivery with the breathing pattern of individual patients is one of the greatest challenges in developing the next generation of smart aerosol delivery devices. Accurate numerical simulation of aerosol deposition is essential for the optimal design and development of these new devices. The presently existing deposition models cannot capture the effect of transient breathing pattern and cannot predict the time dependent local deposition rates. The goal of this project is to develop novel deposition functions for the instantaneous, transient deposition rate of aerosol particles.