Apoptosis regulation by RNA binding proteins

所有细胞都有自我毁灭的能力，这一过程被称为细胞凋亡。细胞凋亡是由各种细胞因子控制的，这些细胞因子被称为蛋白质，它们在需要时产生，例如当细胞缺乏赖以生存的营养物质时。这些与细胞凋亡相关的蛋白质以许多不同的方式起作用，使细胞收缩，将其分解成碎片，并确保残留物被邻近的健康细胞回收利用。如何触发细胞凋亡相关蛋白来执行这些任务是科学界研究的一个活跃领域，尽管已经确定了许多机制，但新的机制经常出现。我们有兴趣研究一种潜在的细胞凋亡控制蛋白RBM10是如何工作的。我们提出RBM10能够促进细胞凋亡，并通过改变各种细胞因子的结构，从而改变它们的功能。我们计划研究RBM10是否以及如何控制细胞凋亡，希望更好地了解细胞是如何调节这一非常重要的过程的。由于细胞死亡的控制是生物体内许多（如果不是全部）其他过程的基础，因此拟议工作的结果有可能对广泛的研究领域产生影响。

All cells have the ability to self-destruct, a process called apoptosis. Apoptosis is controlled by various cellular factors, termed proteins, that are produced when needed - for instance when cells are starved of the nutrients upon which they depend for survival. These apoptosis-related proteins work in many different ways to shrink the cell, break it into pieces and ensure that the remnants are recycled by neighbouring, healthy cells. How the apoptosis-related proteins are triggered to carry out these tasks is an active area of research within the scientific community, and although many mechanisms have been identified, new ones are regularly emerging. We are interested in investigating how one potential apoptosis-controlling protein, RBM10, works. We propose that RBM10 is capable of boosting apoptosis and that it does this by changing the structure of various cellular factors, thereby changing their function. We plan to examine if and how RBM10 controls apoptosis, in the hopes of better understanding how cells, in general, regulate this very important process. Since the control of cell death is fundamental to many - if not all - other processes within living organisms, the results of the proposed work have the potential to impact on a wide range of research areas.