Sleep to remember: sleep-dependent learning and memory in children and adolescents

虽然睡眠依赖的记忆巩固已经在许多物种中得到证实，但我们还不了解睡眠在儿童和青少年的学习和记忆中的作用。我们的长期目标是了解睡眠调节和认知发展之间的相互作用。本应用程序的目的是表征睡眠调节和调节儿童和青少年学习和记忆的系统之间的相互作用。核心假设是，睡眠对儿童和青少年的学习和记忆至关重要。我们进行这项研究的基本原理是，这项研究的成功完成将有助于对儿童和青少年学习和记忆基础的重要见解。我们的贡献预计将是重大的，因为它有望推进我们对大脑发育中至关重要的基本过程的机制理解。我们计划通过追求以下具体目标来检验我们的中心假设并实现我们的目标：1)表征儿童和青少年睡眠与学习/记忆之间的相互作用；2)确定生物钟基因与睡眠对学习和记忆影响的个体差异的相关性。本研究有几个优势：1)基于创新的实验方法；2)它使用先进的客观方法论，克服了该领域以前的方法论挑战；3)这将是第一个研究睡眠在青少年记忆中的作用的研究；4)这将是对这些过程中涉及的遗传机制的第一次检查；5)这将是第一个研究睡眠对青少年情绪和中性信息记忆影响的研究。我们的研究结果将产生重要的积极影响，因为它们有望促进对儿童和青少年睡眠、学习记忆之间相互作用的理解，同时也为各级学生提供独特的多学科培训。这将极大地推动发育神经科学领域的发展。

While sleep-dependent memory consolidation has been shown in numerous species, we do not yet understand the role of sleep in learning and memory in children and adolescents. Our long-term goal is to understand the interplay between the regulation of sleep and cognitive development. The objective of this application is to characterize the interplay between sleep regulation and the systems that regulate learning and memory in children and adolescents. The central hypothesis is that sleep is critical for learning and memory in children and adolescents. Our rationale for this study is that successful completion of the proposed research will contribute important insight into the underpinning of learning and memory in children and adolescents. Our contribution is expected to be significant because it is expected to advance our mechanistic understanding of fundamental processes that are critical in the developing brain. We plan to test our central hypothesis and accomplish our objectives by pursuing the following specific aims: 1) Characterize the Interplay Between Sleep and Learning/Memory in Children and Adolescents; 2) Determine the Relevance of Clock Genes to Individual Differences in the Impact of Sleep on Learning and Memory. This study has several strengths: 1) It is based on an innovative experimental approach; 2) It uses advanced objective methodology that overcomes previous methodological challenges in the field; 3) This will be the first study to examine the role of sleep in memory in adolescents; 4) This will be the first examination of the genetic mechanisms involved in these processes; and, 5) This will be the first study to examine the impact of sleep on memory of emotional vs. neutral information in youth. Our results will have an important positive impact, because they are expected to facilitate the understanding of the interplay among sleep, learning-memory in children and adolescents, while also offering unique multidisciplinary training to students at all levels. This will significantly advance the field of developmental neuroscience.