The role of RanGTP in the spatial organization of mitotic cells

为了使生物体生长和发育，它们必须不断增加体内细胞的数量。 为了达到这个目的，细胞可以分成两部分。 为了使这两个细胞存活下来，它们必须具有生物体遗传物质的完全互补，否则它们将死亡或被错误调节。 因此，细胞分裂必须在遗传物质复制和分离后才发生，否则两个新形成的细胞之间的遗传物质将不均匀分布。 我们有证据表明，每个细胞中的染色体有助于在空间上组织一个细胞，使其只能分裂产生两个具有相同遗传内容的细胞。 我们的目的是确定染色体是如何调节细胞分裂过程的。

For organisms to grow and develop they must continually increase the numbers of cells within them. To achieve this cells can divide into two. For the two resultant cells to survive they must have a complete complement of the organisms genetic material, otherwise they will die or become misregulated. Therefore cell division must only occur once the genetic material has duplicated and separated, otherwise there would be an unequal distribution of the genetic material between the 2 newly forming cells. We have evidence to suggest that the chromosomes in each cells contribute to spatially organizing a cell so that it will only divide to produce two cells with an equal genetic content. We porpose to determine how the chromosomes regulate the process of cell division.