Unprecedented transpositions and their applications in the synthesis of bioactive compounds

合成新的生物活性化合物作为治疗癌症、心血管疾病和其他医院感染的新方法是制药业面临的持续挑战。大多数对这些疾病表现出有用的生物学特性的化合物都具有杂环或多环骨架，如白环素、白新霉素、类固醇、哈美坦、罗通醇和福西替明。不幸的是，这些化合物的天然丰度很低，它们的提取会对我们的生态系统造成破坏。因此，寻找新的合成方法来快速获得这些结构，对于潜在的生物医学应用是非常重要的。在此背景下，本提案中提出的与勃林格-英格尔海姆制药公司合作的合作研究项目致力于

Synthesis of new bioactive compounds as new treatments for cancer, cardiovascular diseases and other nosocomial infections represents a continuing challenge for the pharmaceutical industry. Most of the compounds demonstrating useful biological properties against these diseases possess a heterocyclic or a polycyclic skeleton such as platencin, platensimycin, steroids, hamayne, rotunol and fawcettimine. Unfortunately, the natural abundance of these compounds is low and their extraction causes damage to our ecosystem. Consequently, it is extremely important to discover new synthetic methods to obtain these structures rapidly for potential biomedical application. In this context, the collaborative research project presented in this proposal in collaboration with the pharmaceutical company Boehringer Ingelheim is dedicated