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The role of human glyceraldehyde-3-phosphate dehydrogenase in maintaining the redox state of the DNA repair enzyme APE1

The role of human glyceraldehyde-3-phosphate dehydrogenase in maintaining the redox state of the DNA repair enzyme APE1
人甘油醛-3-磷酸脱氢酶在维持DNA修复酶APE1氧化还原状态中的作用
批准号：
239024
负责人：
Ramotar Dindial
金额：
$45.32万
依托单位：
CIUSSS Est-de-l'Ile-de- Montral-Maisonneuve Rosemont
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-09-01 至 2016-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=239024&lang=en
关键词：
Cell Cycle Dna Repair Genome-Wide Location Analysis Genomic Instability Immunofluorescence Oxidative Dna Damage Oxidized Proteins Post-Translational Modification Protein Structure/Function Analysis Protein-Protein Interactions

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中文摘要
翻译
活性氧物质是高度不稳定的分子，通过线粒体呼吸和激活的中性粒细胞。这些活性氧可以攻击和破坏各种细胞大分子，如蛋白质或酶，
英文摘要
Reactive oxygen species are highly unstable molecules and are produced, e.g., by mitochondrial respiration and activated neutrophils. These reactive oxygen species can attack and destroy various cellular macromolecules such as proteins or enzymes to cause
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The role of human glyceraldehyde-3-phosphate dehydrogenase in reactivating oxidized forms of the DNA repair enzyme APE1
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