Engineering intelligent PLGA nanoparticles for site-specific delivery

制药研究中的一个基本探索是开发药物输送方法，这种方法可以选择性地针对某些细胞，同时限制周围健康细胞对药物的暴露，以避免附带损害。纳米粒子的研究进展迅速，为药物输送提供了令人振奋的希望。聚合物纳米粒是我主要关注的递送系统，是一种多功能的药物递送平台，因为它们具有合适的大小，可被细胞吸收，具有大的表面积，可以进行物理或化学修饰，与其他药物递送系统相比，具有良好的安全性记录。

One fundamental quest in pharmaceutical research is developing methods of drug delivery that can selectively target certain cells, while limiting exposure of surrounding healthy cells to the drug to avoid collateral damage. Advancements in nanoparticles (NPs) are rapidly progressing and offer exciting promise for drug delivery. Polymeric NPs, the delivery system I primarily focus upon, are versatile platforms for drug delivery as they are of appropriate size to be taken up by cells, have a large surface area that can be physically or chemically modified, and an excellent record of safety compared to other drug delivery systems.