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Relationship between denervation, mitochondrial dysfunction, and muscle atrophy in sarcopenia

Relationship between denervation, mitochondrial dysfunction, and muscle atrophy in sarcopenia
肌少症的去神经支配、线粒体功能障碍和肌肉萎缩之间的关系
批准号：
238837
负责人：
Hepple Russell T
金额：
$43.21万
依托单位：
Research Institute of the McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-09-01 至 2016-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=238837&lang=en
关键词：
Aging Immunofluorescence Microscopy Mitochondrial Function Motor Neuron Neuromuscular Junction Permeability Transition Pore Reactive Oxygen Species Respirometry Sarcopenia

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中文摘要
翻译
与年龄相关的肌肉质量和功能丧失的原因被称为石棺减少症，目前尚不清楚。最常见的罪魁祸首之一是线粒体功能的内在缺陷，这一观点得到了线粒体驱动的上调的支持
英文摘要
The causes of the age-related loss of muscle mass and function known as sarcopenia are unknown. Amongst the most frequently implicated culprits is an intrinsic defect in mitochondrial function, an idea supported by the up-regulation of mitochondrial-drive
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